产品详情
简单介绍：
Anti-FADD (Phospho-Ser190) Antibody
详情介绍：
Overview
| Name: | Anti-FADD (Phospho-Ser190) Antibody See all FADD primary antibodies
|
| Description: | Rabbit polyclonal antibody to FADD (Phospho-Ser190) |
| Specificity: | The antibody detects endogenous levels of FADD only when phosphorylated at serine 190. |
| Applications: | WB, IHC |
| Dilutions: | Western blotting: 1:500~1:1000 Immunohistochemistry: 1:50~1:100 |
| Reactivity: | Human, Mouse |
| Immunogen: | Peptide sequence around phosphorylation site of Serine190(N-R-S(p)-G-A) derived from Mouse FADD. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Concentration: | 1.0mg / ml |
| Formulation: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage: | Store at -20?C / 1 year |
Target
| Function: | Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. |
| Tissue Specificity: | Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes. |
| Involvement in Disease: | Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations: A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV). |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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