产品详情
简单介绍：
Anti-FADD Antibody
详情介绍：
Overview
| Name: | Anti-FADD Antibody See all FADD primary antibodies
|
| Description: | Rabbit polyclonal antibody to FADD. |
| Applications: | WB, IHC |
| Dilutions: | WB: 1:500 - 1:2000, IHC: 1:50 - 1:200. |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant protein of human FADD. |
| Protein Length: | 208 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Affinity purification. |
| Product Form: | Liquid |
| Formulation: | Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. |
| Tissue Specificity: | Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes. |
| Involvement in Disease: | Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations: A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV). |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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