产品详情
简单介绍：
Anti-FAM111A (C20) Antibody
详情介绍：
Overview
| Name: | Anti-FAM111A (C20) Antibody See all FAM111A primary antibodies
|
| Description: | Rabbit polyclonal antibody to FAM111A (C20) |
| Specificity: | FAM111A (C20) pAb detects endogenous levels of FAM111A protein. |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | A synthetic peptide corresponding to residues in Human FAM111A. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Molecular Weight: | ~ 70 kDa |
| Purity: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Product Form: | 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. |
Target
| Function: | Chromatin-associated protein required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis (PubMed:24561620). May directly function at replication forks, explaining why Simian virus 40 (SV40) interacts with FAM111A to overcome host range restriction (PubMed:23093934). |
| Involvement in Disease: | Kenny-Caffey syndrome 2: A disorder characterized by impaired skeletal development with small and dense bones, short stature, and primary hypoparathyroidism with hypocalcemia. Clinical features include cortical thickening and medullary stenosis of the tubular bones, delayed closure of fontanels, defective dentition, small eyes with hypermetropia, and frontal bossing with a triangular face. Gracile bone dysplasia: A perinatally lethal condition characterized by narrowing of the medullary cavity of the long bones and of the skull, gracile bones with thin diaphyses, premature closure of basal cranial sutures, and microphthalmia. Most affected individuals who survive beyond the perinatal period develop hypocalcemia with low parathyroid hormone levels. |
| Sequence Similarities: | Belongs to the FAM111 family. |
| Cellular Location: | Nucleus. Cytoplasm. Mainly localizes to nucleus: colocalizes with PCNA on replication sites. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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