产品详情
简单介绍：
Anti-FANCA Antibody
详情介绍：
Overview
| Name: | Anti-FANCA Antibody See all FANCA primary antibodies
|
| Description: | Rabbit polyclonal antibody to FANCA. |
| Applications: | WB, IHC |
| Dilutions: | WB: 1:500 - 1:2000, IHC: 1:50 - 1:200. |
| Reactivity: | Human |
| Immunogen: | Recombinant protein of human FANCA. |
| Protein Length: | 1455 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Affinity purification. |
| Product Form: | Liquid |
| Formulation: | Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. |
| Involvement in Disease: | Fanconi anemia, complementation group A: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. |
| Post-Translational Modification: | Phosphorylation is required for the formation of the nuclear complex. Not phosphorylated in cells derived from groups A, B, C, E, F, G, and H. |
| Cellular Location: | Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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