产品详情
简单介绍：
Anti-FANCC Antibody
详情介绍：
Overview
| Name: | Anti-FANCC Antibody See all FANCC primary antibodies
|
| Description: | Rabbit polyclonal antibody to FANCC |
| Specificity: | The antibody detects endogenous level of total FANCC protein. |
| Applications: | WB, IHC, IF |
| Reactivity: | Human |
| Immunogen: | Recombinant protein of human FANCC. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antibodies were purified by affinity purification using immunogen. |
| Concentration: | 1.0mg / ml |
| Formulation: | Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. |
| Tissue Specificity: | Ubiquitous. |
| Involvement in Disease: | Fanconi anemia complementation group C: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. |
| Cellular Location: | Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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