产品详情
简单介绍：
Anti-FANCG (Phospho-Ser383) Antibody
详情介绍：
Overview
| Name: | Anti-FANCG (Phospho-Ser383) Antibody See all FANCG primary antibodies
|
| Description: | Rabbit polyclonal antibody to FANCG (Phospho-Ser383) |
| Specificity: | The antibody detects endogenous levels of FANCG only when phosphorylated at serine 383. |
| Applications: | WB |
| Dilutions: | Western blotting: 1:500~1:3000 |
| Reactivity: | Human |
| Immunogen: | Peptide sequence around phosphorylation site of serine 383 (R-F-S(p)-P-P) derived from Human FANCG. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Concentration: | 1.0mg / ml |
| Formulation: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage: | Store at -20˚C |
Target
| Function: | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. |
| Tissue Specificity: | Highly expressed in testis and thymus. Found in lymphoblasts. |
| Involvement in Disease: | Fanconi anemia complementation group G: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. |
| Cellular Location: | Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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