产品详情
简单介绍：
Anti-FAT4 Antibody
详情介绍：
Overview
| Name: | Anti-FAT4 Antibody See all FAT4 primary antibodies
|
| Description: | Rabbit polyclonal antibody to FAT4 |
| Specificity: | The antibody detects endogenous levels of total FAT4 protein. |
| Applications: | IHC |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide corresponding to residues near the C terminal of human FAT tumor suppressor homolog 4 (Drosophila) |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification. |
| Concentration: | 0.7mg / ml |
| Formulation: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). |
| Tissue Specificity: | Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer. |
| Involvement in Disease: | Van Maldergem syndrome 2: An autosomal recessive disorder characterized by intellectual disability, typical craniofacial features, auditory malformations resulting in hearing loss, and skeletal and limb malformations. Some patients have renal hypoplasia. Brain MRI typically shows periventricular nodular heterotopia. Hennekam lymphangiectasia-lymphedema syndrome 2: A form of Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymph-vessels dysplasia characterized by intestinal lymphangiectasia with severe lymphedema of the limbs, genitalia and face. In addition, affected individuals have unusual facies and severe mental retardation. HKLLS2 individuals have lymphangiectasia variably affecting the gut, pericardium, lungs, kidneys, and genitalia. Other features include camptodactyly and rare syndactyly. |
| Cellular Location: | Membrane. In the kidney, localizes to primary cilia. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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