产品详情
简单介绍：
Anti-FBL Antibody
详情介绍：
Overview
| Name: | Anti-FBL Antibody See all FBL primary antibodies
|
| Description: | Goat polyclonal antibody to FBL. |
| Applications: | ELISA, WB |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide corresponding to Human FBL (internal region). |
| Sequence: | CRGKEDALVTKN |
| Host: | Goat |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 100 µg at 0.5 mg/ml. |
| Product Form: | Liquid |
| Formulation: | Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239). |
| Sequence Similarities: | Belongs to the methyltransferase superfamily. Fibrillarin family. |
| Post-Translational Modification: | By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA). |
| Cellular Location: | Nucleus > Nucleolus. Fibrillar region of the nucleolus. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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