产品详情
简单介绍：
Anti-FBXL21 Antibody
详情介绍：
Overview
| Name: | Anti-FBXL21 Antibody See all FBXL21 primary antibodies
|
| Description: | Rabbit polyclonal antibody to FBXL21 |
| Applications: | ELISA, WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Rabbit polyclonal FBXL21 (1) antibody was raised against a recombinated human FBXL21 protein 1-138aa (BC106753). |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Affinity purified |
| Concentration: | 1.0mg / ml |
| Formulation: | PBS, pH 7.4 with 0.02% Sodium Azide |
| Storage: | This product is stable for several weeks at 4?C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20?C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
Target
| Function: | Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities. |
| Tissue Specificity: | Expressed in the hypothalamus, especially in the suprachiasmatic nucleus (SCN). Expression is driven by the core-clock. There is a pronounced diurnal and circadian expression rhythms rising rapidly at the start of the day and declining at the onset of the night. |
| Cellular Location: | Cytoplasm > Cytosol. Nucleus. Mainly localizes in the cytosol. Present at low level in the nucleus. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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