产品详情
简单介绍：
Anti-FBXL3 Antibody
详情介绍：
Overview
| Name: | Anti-FBXL3 Antibody See all FBXL3 primary antibodies
|
| Description: | Rabbit polyclonal antibody to FBXL3 |
| Applications: | WB, IF |
| Reactivity: | Human |
| Immunogen: | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 14 and 279 of FBXL3 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Purified by antigen-affinity chromatography. |
| Formulation: | Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative. |
| Storage: | Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use. |
Target
| Function: | Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855). |
| Tissue Specificity: | Widely expressed. |
| Cellular Location: | Nucleus. Cytoplasm. Predominantly nuclear. |
| Database Links: |
|
| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
相关文章
