产品详情
简单介绍：
Anti-FBXL5 Antibody
详情介绍：
Overview
| Name: | Anti-FBXL5 Antibody See all FBXL5 primary antibodies
|
| Description: | Rabbit polyclonal antibody to FBXL5 |
| Applications: | ELISA, WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Rabbit polyclonal FBXL5 (1) antibody was raised against a recombinated human FBXL5 protein 510-691aa (BC030656). |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Affinity purified |
| Concentration: | 1.0mg / ml |
| Formulation: | PBS, pH 7.4 with 0.02% Sodium Azide |
| Storage: | This product is stable for several weeks at 4?C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20?C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
Target
| Function: | Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). |
| Post-Translational Modification: | Ubiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor (By similarity). |
| Cellular Location: | Cytoplasm > Perinuclear region. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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