产品详情
简单介绍：
Anti-FBXO11 Antibody
详情介绍：
Overview
| Name: | Anti-FBXO11 Antibody See all FBXO11 primary antibodies
|
| Description: | Rabbit polyclonal antibody to FBXO11. |
| Applications: | WB, IHC, IF |
| Dilutions: | WB: 1:500 - 1:2000, IHC: 1:50 - 1:100, IF: 1:20 - 1:100. |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant protein of human FBXO11. |
| Protein Length: | 927 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Affinity purification. |
| Product Form: | Liquid |
| Formulation: | Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. |
| Tissue Specificity: | Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes. |
| Cellular Location: | Nucleus. Chromosome. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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