产品详情
简单介绍：
Anti-FBXO31 Antibody
详情介绍：
Overview
| Name: | Anti-FBXO31 Antibody See all FBXO31 primary antibodies
|
| Description: | Rabbit polyclonal antibody to FBXO31 |
| Specificity: | The antibody detects endogenous levels of total FBXO31 protein. |
| Applications: | IHC |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide corresponding to residues near the C terminal of human F-box protein 31 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification. |
| Concentration: | 2.8mg / ml |
| Formulation: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. |
| Tissue Specificity: | Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow. |
| Involvement in Disease: | Mental retardation, autosomal recessive 45: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT45 manifestations include mild to moderate intellectual disability and dysmorphic features, including coarse facies, broad nasal bridge, fleshy nares, and thick, prominent lips. |
| Sequence Similarities: | Belongs to the FBXO31 family. |
| Post-Translational Modification: | Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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