产品类型:

Growth Factor

产品名称:

Recombinant Human Vascular endothelial growth factor A protein(VEGFA) (Active)

uniprot号:

规格:

2ug 10μg 100ug 500ug ￥1,280

基因名称:

VEGFA

别名:

VEGF-A, VPF

种属:

Homo sapiens (Human)

蛋白描述:

Partial of Isoform VEGF165

PubMed ID:

2479986; 2479987; 1711045; 1791831; 1567395; 9054410; 9878851; 9450968; 10464055; 12124351; 19054851; 14574404; 15489334; 7678805; 15340161; 2584205; 10067980; 11563986; 11427521; 11731620; 11978667; 15520188; 14764596; 15896327; 16489009; 22009797; 9207067; 9336848; 9351807; 9922142; 9634701

分子量:

19.3 kDa

标签信息:

Tag-Free

来源:

Yeast

纯度:

>97% as determined by SDS-PAGE and HPLC.

缓冲液:

0.2 μm filtered PBS, pH 7.4, with 0.02 % Tween-20 ,lyophilized

内毒素:

Less than 1.0 EU/μg as determined by LAL method.

生物活性:

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human umbilical vein endothelial cells(HUVEC) is between 1.0-8.0 ng/ml.

Uniprot登录名:

VEGFA_HUMAN

参考文献:

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. {ECO:0000269|PubMed:11427521, ECO:0000269|PubMed:16489009}.

氨基酸序列:

M+APMAEGGGQ NHHEVVKFMD VYQRSYCHPI ETLVDIFQEY PDEIEYIFKP SCVPLMRCGG CCNDEGLECV PTEESNITMQ IMRIKPHQGQ HIGEMSFLQH NKCECRPKKD RARQENPCGP CSERRKHLFV QDPQTCKCSC KNTDSRCKAR QLELNERTCR CDKPRR

表达区域:

27-191aa

研究领域:

Cancer