产品类型:

Recombinant Protein

产品名称:

Recombinant Human C-type lectin domain family 4 member C(CLEC4C),parial IN STOCK

货期:

3-7 工作日

uniprot号:

规格:

1mg 500ug 200ug 100ug 50ug 10ug

图像:

基因名称:

CLEC4C

别名:

Blood dendritic cell antigen 2 ;BDCA-2;C-type lectin superfamily member 7Dendritic lectin; CD303

种属:

Homo sapiens (Human)

蛋白描述:

Extracellular Domain

分子量:

36.0 kDa

标签信息:

N-terminal 6xHis-SUMO-tagged

来源:

E.coli

纯度:

Greater than 90% as determined by SDS-PAGE.

缓冲液:

Tris-based buffer，50% glycerol

生物活性:

Measured by its binding ability in a functional ELISA. Immobilized CLEC4C protein at 1 μg/ml can bind human IgG, the EC50 of human IgG is 31.43-43.52 μg/ml.

参考文献:

Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells.Arce I., Roda-Navarro P., Montoya M.C., Hernanz-Falcon P., Puig-Kroger A., Fernandez-Ruiz E.3.0.CO;2-X>Eur. J. Immunol. 31:2733-2740(2001)

氨基酸序列:

NFMYSKTVKRLSKLREYQQYHPSLTCVMEGKDIEDWSCCPTPWTSFQSSCYFISTGMQSWTKSQKNCSVM
GADLVVINTREEQDFIIQNLKRNSSYFLGLSDPGGRRHWQWVDQTPYNENVTFWHSGEPNNLDERCAIIN
FRSSEEWGWNDIHCHVPQKSICKMKKIYI

简介:

Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not se to bind mannose.

蛋白储存:

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

表达区域:

45-213aa

使用注意:

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

研究领域:

Immunology