产品类型:

Tumor Necrosis Factor

产品名称:

Recombinant Human Tumor necrosis factor receptor superfamily member 11B protein(TNFRSF11B) (Active)

uniprot号:

规格:

10μg 50μg 100μg 250μg ￥620

基因名称:

TNFRSF11B

别名:

Osteoclastogenesis inhibitory factor

种属:

Homo sapiens (Human)

蛋白描述:

Partial

PubMed ID:

9108485; 9492069; 9688283; 14702039; 16421571; 15489334; 9571159; 15340161; 12110935; 9168977; 9603945; 9478964; 11505389; 22664871; 12189164

分子量:

109.6 kDa

标签信息:

C-terminal FC-tagged

来源:

Yeast

纯度:

>95% as determined by SDS-PAGE and HPLC.

缓冲液:

0.2um filtered 20 mM PB, pH 6.0, 150 mM NaCl, 0.02 % Tween-80 ,lyophilized

内毒素:

Less than 1.0 EU/μg as determined by LAL method.

生物活性:

Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml, corresponding to a specific activity of >1.0x10⁵ IU/mg in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).

Uniprot登录名:

TR11B_HUMAN

参考文献:

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269|PubMed:22664871, ECO:0000269|PubMed:9168977}.

氨基酸序列:

ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV CAPCPDHYYT DSWHTSDECL YCSPVCKELQ YVKQECNRTH NRVCECKEGR YLEIEFCLKH RSCPPGFGVV QAGTPERNTV CKRCPDGFFS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQKCGIDVTL+ EPKSSDKTHT CPPCPAPEFE GAPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPTPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK

表达区域:

22-201aa

研究领域:

Immunology