产品类型:

Growth Factor

产品名称:

Recombinant Human Pleiotrophin protein(PTN) (Active)

uniprot号:

规格:

5μg 20μg ￥620

图像:

基因名称:

PTN

别名:

PTN, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule

种属:

Homo sapiens (Human)

蛋白描述:

Full Length of Mature Protein

PubMed ID:

1701634; 2270483; 1768439; 1457401; 8484754; 9299545; 14702039; 12690205; 15489334; 2388713; 1733956; 8241100; 8484780; 11278720; 20873783

分子量:

15.3 kDa

标签信息:

Tag-Free

来源:

E.Coli

纯度:

>96% as determined by SDS?PAGE and HPLC.

缓冲液:

0.2 m filtered PBS, pH 7.4 ,lyophilized

内毒素:

Less than 1.0 EU/μg as determined by LAL method.

生物活性:

Fully biologically active when compared to standard. The biological activity was measured by its ability to enhance neurite outgrowth of E16?E18 rat embryonic cortical neurons, when neurons were plated on 96 well culture plates that had been pre?coated with 100 ?l/well of a solution of 5?10 ug/ml rHuPTN.

Uniprot登录名:

PTN_HUMAN

参考文献:

Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. {ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:1768439}.

氨基酸序列:

GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD

表达区域:

33-168aa

研究领域:

Immunology