产品类型:

Growth Factor

产品名称:

Recombinant Human Noggin protein(NOG) (Active)

uniprot号:

规格:

5μg 20μg 100μg 250μg ￥620

基因名称:

NOG

种属:

Homo sapiens (Human)

蛋白描述:

Full Length of Mature Protein

PubMed ID:

7666191; 15489334; 21976273; 24098149; 12478285; 10080184; 11846737; 11545688; 12089654; 11857750; 15770128; 17668388; 20503332

分子量:

46.3 kDa

标签信息:

Tag-Free

来源:

E.Coli

纯度:

>95% as determined by SDS-PAGE and HPLC.

缓冲液:

0.2 μm filtered 30 % acetonitrile, 0.1 % TFA ,lyophilized

内毒素:

Less than 1.0 EU/μg as determined by LAL method.

生物活性:

Fully biologically active when compared to standard. The ED50 as determined by inhibiting BMP-4- induced alkaline phosphatase production of murine ATDC5 cells is less than 3.0 ng/ml, corresponding to a specific activity of >3.3x10⁵ IU/mg in the presence of 5 ng/ml rHuBMP-4.

Uniprot登录名:

NOGG_HUMAN

参考文献:

Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 (PubMed:21976273). {ECO:0000269|PubMed:12478285, ECO:0000269|PubMed:21976273}.

氨基酸序列:

M+QHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC

表达区域:

28-232aa

研究领域:

Stem Cells?