产品类型:

Growth Factor

产品名称:

Recombinant Human Platelet-derived growth factor subunit B protein(PDGFB) (Active)

uniprot号:

规格:

2μg 10μg 100μg 250μg ￥620

基因名称:

PDGFB

别名:

PDGF subunit B, Platelet-derived growth factor B chain, Platelet-derived growth factor beta polypeptide, Proto-oncogene c-Sis, Becaplermin

种属:

Homo sapiens (Human)

蛋白描述:

Full Length of Mature Protein

PubMed ID:

6740330; 4033772; 2991848; 3472769; 3517869; 15461802; 10591208; 15489334; 7659502; 8988177; 6327048; 3456904; 6306471; 6844921; 6329745; 1661670; 1317862; 11331882; 12660034; 18483217; 1396586; 20534510; 23913003

分子量:

24.8 kDa

标签信息:

Tag-Free

来源:

E.Coli

纯度:

>97% as determined by SDS-PAGE and HPLC.

缓冲液:

0.2 μm filtered PBS, pH 7.4 ,lyophilized

内毒素:

Less than 1.0 EU/μg as determined by LAL method.

生物活性:

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 3 ng/ml, corresponding to a specific activity of >3.3x10⁵ IU/mg.

Uniprot登录名:

PDGFB_HUMAN

参考文献:

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250}.

氨基酸序列:

M+SLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC ETVAAARPVT

表达区域:

82-190aa

研究领域:

Cancer