产品类型:

Growth Factor

产品名称:

Recombinant Human Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor protein(HBEGF) (Active)

uniprot号:

规格:

10μg 50μg 100μg 250μg ￥620

图像:

基因名称:

HBEGF

别名:

HB-EGF, Diphtheria toxin receptor, DT-R,]

种属:

Homo sapiens (Human)

蛋白描述:

Full Length of Mature Protein

PubMed ID:

1840698; 14702039; 15372022; 15489334; 1556128; 7836353; 9135143; 16508205; 22171320; 23234360; 9659904

分子量:

9.7 kDa

标签信息:

Tag-Free

来源:

E.Coli

纯度:

>97% as determined by SDS-PAGE and HPLC.

缓冲液:

0.2 μm filtered 20 mM PB, pH 7.4, 130 mM NaCl ,lyophilized

内毒素:

Less than 1.0 EU/μg as determined by LAL method.

生物活性:

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 1 ng/ml, corresponding to a specific activity of >1.0x10⁶ IU/mg.

Uniprot登录名:

HBEGF_HUMAN

参考文献:

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

氨基酸序列:

DLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLG KKRDPCLRKY KDFCIHGECK YVKELRAPSC ICHPGYHGER CHGLSL

表达区域:

63-148aa

研究领域:

Cancer