产品类型:

Other

产品名称:

Recombinant Human SPARC protein(SPARC) (Active)

uniprot号:

规格:

10μg 50μg 100μg 250μg ￥620

图像:

基因名称:

SPARC

别名:

Basement-membrane protein 40, Osteonectin, ON, Secreted protein acidic and rich in cysteine

种属:

Homo sapiens (Human)

蛋白描述:

Full Length of Mature Protein

PubMed ID:

3410046; 2838412; 2790009; 2338025; 15489334; 17974005; 3597437; 2306517; 3400777; 7495300; 9457905; 8548457; 9233787; 9501084

分子量:

36.1 kDa

标签信息:

N-terminal 6xHis-tagged

来源:

E.Coli

纯度:

>95% as determined by SDS-PAGE and HPLC.

缓冲液:

0.2 μm filtered PBS, pH 7.4 ,lyophilized

内毒素:

Less than 1.0 EU/μg as determined by LAL method.

生物活性:

Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the cell growth of Mv1Lu mink lung epithelial cells is less than 3.0 ug/mL, corresponding to a specific activity of >333 IU/mg.

Uniprot登录名:

SPRC_HUMAN

参考文献:

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium s; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

氨基酸序列:

MSYYHHHHHH DYDIPTTENL YFQGAMGSA+P QQEALPDETE VVEETVAEVT

EVSVGANPVQ VEVGEFDDGA EETEEEVVAE NPCQNHHCKH GKVCELDENN

TPMCVCQDPT SCPAPIGEFE KVCSNDNKTF DSSCHFFATK CTLEGTKKGH

KLHLDYIGPC KYIPPCLDSE LTEFPLRMRD WLKNVLVTLY ERDEDNNLLT

EKQKLRVKKI HENEKRLEAG DHPVELLARD FEKNYNMYIF PVHWQFGQLD

QHPIDGYLSH TELAPLRAPL IPMEHCTTRF FETCDLDNDK YIALDEWAGC

FGIKQKDIDK DLVI

表达区域:

18-303aa

研究领域:

Cancer