产品类型:

Growth Factor

产品名称:

Recombinant Human Insulin-like growth factor I protein(IGF1) (Active)

uniprot号:

规格:

100μg 1mg ￥620

图像:

基因名称:

IGF1

别名:

IGF-I, MGF, Somatomedin-C

种属:

Homo sapiens (Human)

蛋白描述:

Full Length of Mature Protein

PubMed ID:

6358902; 3002851; 2935423; 2937782; 3455760; 2082190; 2018498; 1372070; 8495408; 16541075; 15489334; 6382022; 632300; 3242681; 21076856; 24132240; 6189745; 2036417; 1319992; 8857020; 10391209

分子量:

9.1 kDa

标签信息:

Tag-Free

来源:

E.Coli

纯度:

>95% as determined by SDS?PAGE and HPLC.

缓冲液:

0.2 m filtered PBS, pH 7.0 ,lyophilized

内毒素:

Less than 1.0 EU/μg as determined by LAL method.

生物活性:

Fully biologically active when compared to standard. The ED50 as determined by the stimulation of protein synthesis using rat L6 myoblasts is less than 10 ng/ml, corresponding to a specific activity of >1.0x10⁵ IU/mg.

Uniprot登录名:

IGF1_HUMAN

参考文献:

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. {ECO:0000269|PubMed:21076856, ECO:0000269|PubMed:24132240}.

氨基酸序列:

MFPAMPLSSL FVNGPR+TLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA

表达区域:

49-118aa

研究领域:

Cancer