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  • 产品名称:Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein(NRG1) (Activ

  • 产品型号:
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简单介绍:
Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein(NRG1) (Active)
详情介绍:
  • 产品类型:
    Growth Factor
  • 产品名称:

    Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein(NRG1) (Active)

  • uniprot号:
  • 规格:
    ¥620
  • 图像:
  • 基因名称:
    NRG1
  • 别名:
    Pro-NRG1, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin
  • 种属:
    Homo sapiens (Human)
  • 蛋白描述:
    Partial of Isoform 11
  • PubMed ID:
    1350381; 7509448; 8096067; 7782315; 14702039; 16421571; 9333014; 12145742; 17565985; 15489334; 7689552; 1348215; 7902537; 10523851; 10597312; 10867024; 8062828; 8639490
  • 分子量:
    7.5 kDa
  • 标签信息:
    Tag-Free
  • 来源:
    E.Coli
  • 纯度:
    >97% as determined by SDS-PAGE and HPLC.
  • 缓冲液:
    0.2 m filtered 1 x PBS, pH 7.4, with 5 % trehalose ,lyophilized
  • 内毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 0.5 ng/ml, corresponding to a specific activity of >2.0x106 IU/mg.
  • Uniprot登录名:
    NRG1_HUMAN
  • 参考文献:
    Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. {ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:7902537}.
  • 氨基酸序列:
    SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
  • 表达区域:
    122-186aa
  • 研究领域:
    Neuroscience?
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