产品类型:

Tumor Necrosis Factor

产品名称:

Recombinant Rhesus Macaque Tumor necrosis factor protein(TNF) (Active)

uniprot号:

规格:

5μg 25μg 100μg 250μg ￥620

图像:

基因名称:

TNF

别名:

Cachectin, Tumor necrosis factor ligand superfamily member 2, TNF-a, , NTF

种属:

Macaca mulatta (Rhesus macaque)

蛋白描述:

Partial

PubMed ID:

7561102; 15269276;

分子量:

17.3 kDa

标签信息:

Tag-Free

来源:

E.Coli

纯度:

>95% as determined by SDS-PAGE and HPLC.

缓冲液:

0.2 μm filtered PBS, pH 7.4, 5 % trehalose ,lyophilized

内毒素:

Less than 1.0 EU/μg as determined by LAL method.

生物活性:

Fully biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 0.05 ng/ml, corresponding to a specific activity of >2.0x10⁷ IU/mg in the presence of actinomycin D.

Uniprot登录名:

TNFA_MACMU

参考文献:

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. {ECO:0000250}.

氨基酸序列:

VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELTDNQLVV PSEGLYLIYS QVLFKGQGCP SNHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINLPD YLDFAESGQV YFGIIAL

表达区域:

77-233aa

研究领域:

Cancer