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  • 产品名称:Recombinant Mouse Interleukin-36 beta protein(Il36b) (Active)

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简单介绍:
Recombinant Mouse Interleukin-36 beta protein(Il36b) (Active)
详情介绍:
  • 产品类型:
    Interleukin
  • 产品名称:

    Recombinant Mouse Interleukin-36 beta protein(Il36b) (Active)

  • uniprot号:
  • 规格:
    ¥620
  • 图像:
  • 基因名称:
    Il36b
  • 别名:
    Interleukin-1 family member 8
  • 种属:
    Mus musculus (Mouse)
  • 蛋白描述:
    Full Length
  • PubMed ID:
    11991723; 16141072; 19717513; 21860022; 21965679
  • 分子量:
    20.9 kDa
  • 标签信息:
    Tag-Free
  • 来源:
    E.Coli
  • 纯度:
    >95% as determined by SDS-PAGE and HPLC.
  • 缓冲液:
    0.2 μm filtered 20 mM Tris, 300 mM NaCl, pH 8.0, 5 % trehalose ,lyophilized
  • 内毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    Fully biologically active when compared to standard. The specific activity determined by its ability in a functional ELISA. Immobilized rMuIL-36β at 1 ug/mL can bind recombinant murine IL-1 Rrp2 with a range of 0.15-5 ug/mL.
  • Uniprot登录名:
    IL36B_MOUSE
  • 参考文献:
    Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activates p38 MAPK phosphorylation in BMDCs. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by T helper 1 (Th1) cells, cultured CD4(+) T cells and splenocytes. {ECO:0000250|UniProtKB:Q9NZH7, ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679}.
  • 氨基酸序列:
    MMAFPPQSCV HVLPPKSIQM WEPNHNTMHG SSQSPRNYRV HDSQQMVWVL TGNTLTAVPA SNNVKPVILS LIACRDTEFQ DVKKGNLVFL GIKNRNLCFC CVEMEGKPTL QLKEVDIMNL YKERKAQKAF LFYHGIEGST SVFQSVLYPG WFIATSSIER QTIILTHQRG KLVNTNFYIE SEK
  • 表达区域:
    1-183aa
  • 研究领域:
    Immunology
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