产品类型:

Interleukin

产品名称:

Recombinant Mouse Interleukin-21 protein(Il21) (Active)

uniprot号:

规格:

2μg 10μg 100μg 250μg ￥620

图像:

基因名称:

Il21

别名:

IL-21

种属:

Mus musculus (Mouse)

蛋白描述:

Full Length of Mature Protein

PubMed ID:

11081504; 11970879; 12893770; 15100251

分子量:

15.0 kDa

标签信息:

Tag-Free

来源:

E.Coli

纯度:

>98% as determined by SDS-PAGE and HPLC.

缓冲液:

0.2 m filtered 2 x PBS, pH 7.4 ,lyophilized

内毒素:

Less than 1.0 EU/μg as determined by LAL method.

生物活性:

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human N1186 T cells is less than 25 ng/ml, corresponding to a specific activity of >4.0x10⁴ IU/mg.

Uniprot登录名:

IL21_MOUSE

参考文献:

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. {ECO:0000250, ECO:0000269|PubMed:11970879, ECO:0000269|PubMed:12893770, ECO:0000269|PubMed:15100251}.

氨基酸序列:

HKSSPQGPDR LLIRLRHLID IVEQLKIYEN DLDPELLSAP QDVKGHCEHA AFACFQKAKL KPSNPGNNKT FIIDLVAQLR RRLPARRGGK KQKHIAKCPS CDSYEKRTPK EFLERLKWLL QKMIHQHLS

表达区域:

18-146aa

研究领域:

Immunology