产品类型:

Colony Stimulating Factor

产品名称:

Recombinant Human Macrophage colony-stimulating factor 1 protein(CSF1) (Active)

uniprot号:

规格:

2μg 10μg 100μg 250μg ￥620

基因名称:

CSF1

别名:

CSF-1, MCSF, Lanimostim

种属:

Homo sapiens (Human)

蛋白描述:

Partial

PubMed ID:

2996129; 3493529; 2460758; 2660794; 14702039; 16710414; 15489334; 3500041; 1791839; 8262907; 3498652; 3259875; 3039346; 3264877; 1531650; 8422357; 15519852; 16337366; 18687298; 19934330; 20829061; 20504948; 22171320; 23234360; 26091039; 1455231

分子量:

36.8 kDa

标签信息:

Tag-Free

来源:

E.Coli

纯度:

>95% as determined by SDS-PAGE and HPLC.

缓冲液:

0. 2um filtered PBS, pH7.4 ,lyophilized

内毒素:

Less than 1.0 EU/μg as determined by LAL method.

生物活性:

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine M-NFS-60 cells is less than 1 ng/ml, corresponding to a specific activity of >1.0x10⁶ IU/mg.

Uniprot登录名:

CSF1_HUMAN

参考文献:

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. {ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.

氨基酸序列:

EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL QELSLRLKSC FTKDYEEHDK ACVRTFYETP LQLLEKVKNV FNETKNLLDK DWNIFSKNCN NSFAECSSQG HERQSEGS

表达区域:

33-181aa

研究领域:

Immunology