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  • 产品名称:Recombinant Human C-C motif chemokine 4 protein(CCL4) (Active)

  • 产品型号:
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简单介绍:
Recombinant Human C-C motif chemokine 4 protein(CCL4) (Active)
详情介绍:
  • 产品类型:
    Chemokine
  • 产品名称:

    Recombinant Human C-C motif chemokine 4 protein(CCL4) (Active)

  • uniprot号:
  • 规格:
    ¥620
  • 图像:
  • 基因名称:
    CCL4
  • 别名:
    G-26 T-lymphocyte-secreted protein, Lymphocyte activation gene 1 protein, LAG-1, MIP-1-beta1-69
  • 种属:
    Homo sapiens (Human)
  • 蛋白描述:
    Partial of NM_207007.3
  • PubMed ID:
    2462251; 2521882; 2521353; 2247088; 2568930; 1894635; 15843566; 16625196; 15489334; 2809212; 9521068; 8525373; 10540332; 12070155; 12401480; 8134838
  • 分子量:
    7.8 kDa
  • 标签信息:
    Tag-Free
  • 来源:
    E.Coli
  • 纯度:
    >97% as determined by SDS-PAGE and HPLC.
  • 缓冲液:
    0.2 μm filtered PBS, pH 7.4 ,lyophilized
  • 内毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human CCR5 transfected murine BaF3 cells is less than 2.0 ng/ml, corresponding to a specific activity of >5.0x105 IU/mg.
  • Uniprot登录名:
    CCL4_HUMAN
  • 参考文献:
    Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:12070155, ECO:0000269|PubMed:8525373}.
  • 氨基酸序列:
    APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN
  • 表达区域:
    24-92aa
  • 研究领域:
    Immunology
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