TP53 Monoclonal Antibody

规格:

￥2383

免疫原:

Purified recombinant human p53 protein fragments expressed in E.coli.

宿主:

Mouse

种属反应性:

Human

特异性:

This antibody detects endogenous levels of p53 and does not cross-react with related proteins.

应用范围:

ELISA,WB;Recommended dilution:WB:1:500-1:5000

背景:

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

克隆类型:

Monoclonal

抗体亚型:

IgG2b

纯化方式:

Affinity purified

产品提供形式:

Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.

储存条件:

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

别名:

P53; LFS1; TRP53; TP53