产品类型:

Monoclonal antibodies

产品名称:

SMAD2 Monoclonal Antibody

规格:

100μl ￥2383

免疫原:

Purified recombinant human SMAD2 protein fragments expressed in E.coli.

宿主:

Mouse

种属反应性:

Human

特异性:

This antibody detects endogenous levels of SMAD2 and does not cross-react with related proteins.

应用范围:

ELISA,WB,ICC;Recommended dilution:WB:1:500-1:5000,ICC:1:50-1:200

背景:

 Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and,on formation of the SMAD2/SMAD4 complex,activates transcription.May act as a tumor suppressor in colorectal carcinoma.Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

克隆类型:

Monoclonal

抗体亚型:

IgG1

产品提供形式:

Ascites

储存条件:

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

别名:

hMAD 2; hMAD-2; hSMAD2; JV18 1; JV18; JV18; JV18-1; JV181; MAD; MAD; MAD homolog 2; MAD Related Protein 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mothers Against Decapentaplegic Homolog 2; Mothers Against Decapentaplegic Homolog 2;