NM_006231.3

CRCS12; FILS; POLE1

Homo sapiens polymerase (DNA directed), epsilon, catalytic subunit(POLE), mRNA.

5426

atgtctctgaggagcggcgggcggcggcgcgcggacccaggcgcggatggcgaggccagcagggatgatg
gcgccacttcctcagtttcggcactcaagcgcctggaacggagtcagtggacggataagatggatttgcg
gtttggttttgagcggctgaaggagcctggtgagaagacaggctggctcattaacatgc****taccgag
attttagatgaagataagcgcttaggcagtgcagtggattactactttattcaagatgacggaagcagat
ttaaggtggctttgccctataaaccgtatttctacattgcgaccagaaagggttgtgagcgagaagtttc
atcttttctctccaagaagtttcagggcaaaattgcaaaagtggagactgtccccaaagaggatctggac
ttgccaaatcacttggtgggtttgaagcgaaattacatcaggctgtccttccacactgtggaggatcttg
tcaaagtgaggaaggagatctcccctgccgtgaagaagaacagggagcaggatcacgccagcgacgcgta
cacagctctgctttccagtgttctgcagaggggcggtgtcattactgatgaagaggaaacctctaagaag
atagctgaccagttggacaacattgtggacatgcgcgagtacgatgttccctaccac****gcctctcca
ttgacctgaag****acgtggctcattggtacaatgtcagataccgaggaaatgcttttccggtagaaat
cacccgccgagatgaccttgttgaacgacctgaccctgtggttttggcatttgacattgagacgaccaaa
ctgcccctcaagtttcctgatgctgagacagaccagattatgatgatttcctacatgatcgatggccagg
gctacctcatcaccaacagggagattgtttcagaagatattgaagattttgagttcacccccaagccaga
atatgaaggccccttttgtgtcttcaatgaacccgatgaggctcatctg****aaaggtggtttgaacac
gtccaggagaccaaacccaccatcatggtcacctacaacggggacttttttgactggccatttgtggagg
cccgggcagcagtccacggtctgagcatgcagcaggagataggcttccagaaggacagccagggggagta
caaggcgccccagtgc****acatggactgcctcaggtgggtgaagagggacagttaccttcctgtgggc
agtcataatctcaaggcggccgccaaggccaagctaggctatg****cgtggagctagacccggaggaca
tgtgccggatggccacggagcagccccagactctggccacgtattctgtgtcagatgctgtcgccactta
ctacctgtacatgaagtacgtccacccattcatctttgctctgtgcaccattattcccatggagcccgac
gaggtgctgcggaagggctctggcactctgtgtgaggccttgctgatggtgcaggccttccacgccaaca
tcatcttccccaacaagcaagagcaggagttcaataagctgacggacgacggacacgtgctggactctga
gacctacgtcgggggccacgtggaggccctcgagtctggggttttccgcagcgat****cttgccggttt
aggatga****tgccgcctttgacttcctgctgcagcgggttgagaagaccttgcgccacgcccttgagg
aagaggagaaagtgcctgtggagcaagtcaccaactttgaagaggtgtgtgatgagattaagagcaagct
tgcctccctgaaggacgttcccagccgcatcgagtgtccactcatctaccacctggacgtgggggccatg
taccccaacatc****tgaccaaccgcctgcagccctctgccatggtggacgaagccacctgtgctgcct
gtgacttcaataagcctggagcaaactgccagcggaagatggcctggcagtggaggggcgagttcatgcc
agccagtcgcagcgaataccatcgg****agcaccagctggagtcagagaagttcccccccttgttccca
gaggggccagctcgggcctttcatgaactgtcccgcgaggaacaggcgaaatacgagaagagaaggctgg
cggattactgccggaaagcctacaagaag****acatcaccaaggtggaagagcgtctcaccaccatctg
ccagcgggaaaactccttctacgtggacaccgtgcgtgccttccgggacaggcgttacgagttcaaaggg
ctccacaaggtgtggaaaaagaagctctcggcggccgtggaggtgggcgacgcggctgaggtgaagcgct
gcaagaacatggaggtgctgtatgactcgctgcagctggcccacaagtgc****tgaactccttctatgg
ctatgtcatgcgcaagggggctcgctggtactccatggagatggctggcatcgtctgcttcacaggggcc
aacatcatcacccaggcacgggagctgatcgagcagattgggaggcccttagagctggacacagatggta
tatggtgcgtcctgcccaacagcttcccagaaaattttgtcttcaagacgaccaatgtgaagaagcccaa
agtgaccatctcctacccaggcgccatgttgaacatcatggtcaaggaaggcttcaccaatgaccagtac
caggagctggctgagccgtcctcactcacctacgtcacccgctcagagaacagcatcttttttgaggttg
atgggccctaccttgccatgattcttccagcctccaaggaagaaggcaagaaattgaagaagaggtatgc
tgtgttcaatgaagacggttctctggctgagctcaagggctttgaggtcaaacgccgcggggaactgcag
ctgattaagatcttcca****tcggtgtttgaggccttcctcaagggcagcacgctggaagaggtgtatg
gctctgtagccaaggtggctgactactggctggacgtgctgtacagcaaggcagccaacatgcctgactc
tgagctattcgagctcatctctgagaaccgttccatgtctcggaagctggaagattacggggagcagaag
tctacgtccatcagcacagcaaagcgcctggccgagttcctgggagaccagatggtcaaggatgcagggc
tgagttgccgctacatcatctcccgcaagcccgagggctcccctgtcacggagagggcc****cacttgc
cattttccaagcagagcccacggtgaggaagcactttctccggaaatggctcaagagctcttcccttcaa
gactttgatattcgagcaattctggattgggactactacattgagcggctgggaagcgcc****agaaga
tcatcacc****ctgcggccctgcagcaggtaaagaacccagtgccacgtgtcaaacaccccgactggct
gcacaaaaaactgctggagaagaatgatgtctacaagcagaagaagatcagtgagctcttcaccctggag
ggcaggagacaggtcacgatggccgaggcctcagaagacagtccgaggccaagtgctcctgacatggagg
acttcggcctcgtaaagctgcctcacccagcagcccctgtcactgtgaagaggaagcgagttctttggga
gagccaggaggagtcccaggacctcacgccgactgtgccctggcaggaaatcttggggcagcctcccgcc
ctgggaaccagccaggaggaatggcttgtctggctccggttccacaagaagaagtggcagctgcaggccc
ggcagcgcctcgcccgcaggaagaggcagcgtctggagtcggcagagggtgtgctcaggcccggggccat
ccgggatggtcctgccacggggctggggagcttcttgcgaagaactgcccgcagc****tggaccttccg
tggcagattgtgcagatcagcgagaccagccaggccggcctgttcaggctgtgggcgctcgttggcagtg
acttgcactgcatcaggctgagc****cccgtgtgttctacgtgaaccagcgagtcgctaaagcggagga
gggtgcttcgtatcgcaaggtaaatcgggtccttcctcgctccaacatggtctacaatctctatgagtat
tcagtgccagaggacatgtaccaggaacacatcaacgagatcaacgctgagctgtcagcgccagacatcg
agggcgtatatgagactcaggttccgttactgttccgggccctggtgcacctgggctgtgtgtgtgtggt
caataaacagctggtgaggcacctttcaggctgggaagcagagacctttgctcttgagcacctggagatg
cgctctctggcccagttcagctacctggaaccagggagt****gccatatctacctgtaccaccacgcac
aggcccacaaagcgctcttcgggatcttc****cctcacagcgcagggc****gtctttgtgctggacac
tgtgcgcagcaaccagatgcccagccttggcgccctgtactcagcagagcacggcctcctcctggagaag
gtgggccctgagctcctgccaccccccaaacacaccttcgaagttcgggcagaaactgacctgaagacca
tctgcagagcc****agcgattcctgctcgcctacaaggaggagcgccgggggcccacactcatcgctgt
tcagtccagctgggagctgaagaggctggccagtgaaattcctgtcttggaggaattcccactggtgcct
atctgtgtggctgacaagatcaactatggggtcctggactggcagcgccatggagcccggcgcatg****
gtcactacctcaacctggacacctgcctgtcgcaggccttcgagatgagcaggtactttcacattcccat
tgggaacctaccagaggacatctccacattcggctccgacctcttctttgcccgccacctccagcgccac
aaccacctgctctggctgtcccctacagcccgccctgacctgggtggaaaggaggctgatgacaactgtc
ttgtcatggagttcgatgaccaagccactgttgagatcaacagttcaggctgttactccacagtgtgtgt
ggagctggaccttcagaacctggccgtcaacaccattctccagtctcaccatgtcaacgacatggagggg
gccgacagcatggggatcagcttcgacgtg****agcaggcctccctggaggacatgatcacgggtggtc
aggctgccagtgccccggccagctacgatgagacagccctgtgctctaacaccttcagg****tgaagag
catggtcgtgggctgggtgaaggagatcacccagtaccacaacatctatgcagacaaccaggtgatgcac
ttctaccgctggcttcggtcgcc****tctctgcttcatgaccctgccctgcaccgcacactccacaaca
tgatgaagaagctcttcctgcagctcatcgctgagttcaagcgcctggggtcatcagtcatctacgccaa
cttcaaccgcatc****tctgtacaaagaagcgccgtgtggaagatgccatcgcttacgtggagtacatc
accagcagc****attcaaaggagaccttccattctctgacaatttctttctctcgatgctgggaatttc
ttctctggatgg****atctaactatggcggaatcaaaggaaaagtttcatctcgtattcactgtggact
gcaagactcccagaaagcagggggagcagaggatgagcaggaaaatgaggacgatgaggaggaaagagat
ggggaggaggaggaagaggcggagga****aacgtggaggatttactggaaaacaactggaacattttgc
agtttttgccacaggcagcctcctgccagaactacttcctcatgattgtttcagcgtacatcgtggccgt
gtaccactgcatgaaggacgggctgaggcgcagtgctccagggagcacccccgtgaggaggaggggggcc
agccagctctcccaggaggccgagggggcggtcggagcccttcccggaatgatcaccttctctcaggatt
atgtcgcaaatgagctcactcagagcttcttcaccatcactcagaagattcagaagaaagtcacaggctc
tcggaactccactgagctctcagagatgtttcctgtcctccccggttcccacttgctgctcaataaccct
gccctggagttcatcaaatacgtgtgcaaggtgctgtccctggacaccaacatcacaaaccaggtgaata
agctgaaccgagacctgcttcgcctggtggatgtcggcgagttctccgaggaggcccagttccgagaccc
ctgccgctcctacgtgcttcctgaggtcatctgccgcagctgtaacttctgccgcgacctggacctgtgt
aaagactcttccttctcagaggatggggcggtcctgcctcagtggctctgctccaactgtcaggcgccct
acgactcctctgccatcgagatgacgctggtggaagttctacagaagaagctgatggccttcaccctgca
ggacctggtctgcctgaagtgccgcggggtgaaggagaccagcatgcctgtgtactgcagctgcgcggga
gacttcgccctcacc****acacccaggtcttcatggaacagatcggaatattccggaacattgcccagc
actacggcatgtcgtacctcctggagaccctggagtggctgctgcagaagaacccacagctgggccatta
g

pUC

62198237

MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADKINYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGAVGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQKNPQLGH

210..7070

6861

1..8024

8024

12q24.3

12