Recombinant Ebolavirus BDBV (subtype Bundibugyo,strain Uganda 2007) Small/secreted Glycoprotein (sGP) produced in HEK293 cells, incorporating a C-terminal 6x His-tag. Greater than 80% purity.
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Ebola virus secreted glycoprotein (sGP)
Ebola virus secreted glycoprotein protein (sGP) is Ile 33 – Arg 324 (Accession # B8XCN1), fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 34.3 kDa. The protein is expressed in HEK293 cells. DTT-reduced Protein migrates as 40-55 kDa in SDS-PAGE.
The virulence of EBOV may be partially attributed to the Ebola virus secreted glycoprotein (sGP), which is the main product transcribed from its GP gene. Ebola virus secreted glycoprotein is secreted from infected cells and can be readily detected in the serum of EBOV-infected hosts. Mature sGP is produced from a precursor by proteolytic cleavage by host cell proteases such as furin. sGP monomers bind to each other to form a homodimer.
The role of Ebola virus secreted glycoprotein in EBOV pathogenesis is unclear, but is examined in detail by de la Vega et al (2015)
****SHIPPING AND STORAGE NOTIFICATION: This recombinant protein has been lyophilised to maximise stability. It is shipped at ambient temperature, and may be stored for up to 1 year at 4C prior to reconstitution. Following reconstitution it should be stored at -80C. Extensive stability tests have shown no negative effects on antigen performance for 7 days of shipping at ambient temperature.
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