Staphylococcus enterotoxin G antibody – clone SEG-59

Mouse anti Staphylococcus aureus enterotoxin G antibody (clone SEG-59) recognises enterotoxin type G. The antibody is suitable for use in ELISA and Western blotting applications. Clone SEG-59 (MAB12247) can be used as a capture antibody with clone SEG-16 (MAB12248) in ELISA assays.

Staphylococcus aureus (S.aureus) is a gram-positive, non-spore forming bacterium that is a member of the genus Staphylococcus, which belongs to the family Staphylococcaceae. First recognised in 1880, S.aureus exists in many individuals as part of the normal microbiota, inhabiting the skin, nasal passages and respiratory tract. Pathogenic S.aureus secrete a range of potent toxins, which are a major cause of a wide range of pathogenic conditions in humans worldwide.

Enterotoxins, produced by S.aureus, are a major cause of food poisoning. Over 30 enterotoxins have been identified to date. Staphylococcus aureus enterotoxin B (SEB) and SEA are recognised as the most potent enterotoxin within the Staphylococcal family of toxin. SEB and SEA enterotoxin also acts as a potent bacterial superantigen, stimulating T lymphocytes and binding to major histocompatibility antigens (MHC) on antigen presenting cells of the immune system. Two separate domains on the 28kDa SEB protein are reported to be responsible for the two different functions of the toxin (Fries, B).

Staphylococcus aureus enterotoxins G and I have been associated with minor food poisoning outbreaks in Taiwan. Both toxins are heat stable and are transmitted to humans via contaminated foods including meat, meat products and unpasteurised dairy products. Both enterotoxin I and G have also been linked to cases of toxic shock syndrome, Staphylococcal scarlet fever and neonatal entropathy.

References:

Fries BC, Varshney AK. 2013. Bacterial Toxins-Staphylococcal Enterotoxin B. Microbiol Spectr. Dec;1(2)

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