产品详情
简单介绍：
重组人NOGGIN蛋白 rhNOGGIN
详情介绍：
Noggin belongs to a group of diffusible proteins which bind to ligands
of the TGF-α family and regulate their activity by inhibiting their
access to signaling receptors. Noggin was originally identified as a
BMP-4 antagonist whose action is critical for proper formation of the
head and other dorsal structures. Consequently, Noggin has been shown to
modulate the activities of other BMPs including BMP-2,-7,-13, and -14.
Targeted deletion of Noggin in mice results in prenatal death and
recessive phenotype displaying a severely malformed skeletal system.
Conversely, transgenic mice over-expressing Noggin in mature osteoblasts
display impaired osteoblastic differentiation, reduced bone formation,
and severe osteoporosis. The amino acid sequence of human noggin is
highly homologous to that of Xenopus, rat and mouse.
| 货号 | 108-09 |
| 产地 | 美国 |
| 缩写 | rhNOGGIN |
| 规格 | 5 μg |
| 用途 | 科研 |
| 储存 | -20度 |
| 运输 | 干冰 |
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