FITC - anti Human, Feline (cat), Rabbit CD81 - MEM-38
| Reference | Size | Price | Quantity | Add to cart |
|---|---|---|---|---|
| 81F-100T | 100 test |
375,00 € tax excl.
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Product Description
- MEM-38
- IgG1
- Flow cytometry
- FITC
- Please refer to the Certificate of Analysis for the lot-specific concentration.
- MOLT-4 (human T-ALL cell line)
- Human, Feline (cat), Rabbit
- The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
- RUO
- CD81, clone M38, is a mAb intended for identification of TAPA-1. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/106 cells.
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This antibody reacts with the CD81-antigen, which is a widely expressed cell-surface protein involved in an astonishing variety of biologic responses. It has been cloned independently several times for different functional effects and is reported to influence adhesion, morphology, activation, proliferation, and differentiation of B, T, and other cells. On B cells CD81 is part of a complex with CD21, CD19, and Leu13. This complex reduces the threshold for B cell activation via the B cell receptor by bridging Ag specific recognition and CD21-mediated complement recognition. Similarly on T cells CD81 associates with CD4 and CD8 and provides a costimulatory signal with CD3. CD81 is also physically and functionally associated with several integrins. Anti-CD81 can activate integrin alpha 4 beta 1 (VLA-4) on B cells, facilitating their adhesion to tonsilar interfollicular stroma.
- TAPA-1, target of an antiproliferative antibody.
- 975
- 26 kDa
