产品详情
简单介绍：
Anti-TIRAP Antibody
详情介绍：
Overview
| Name: | Anti-TIRAP Antibody See all TIRAP primary antibodies
|
| Description: | Goat polyclonal antibody to TIRAP. |
| Applications: | ELISA, WB |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide corresponding to Human TIRAP (C terminal). |
| Sequence: | C-EGEGERDSATVSDL |
| Host: | Goat |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 100 µg at 0.5 mg/ml. |
| Product Form: | Liquid |
| Formulation: | Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. |
| Tissue Specificity: | Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain. |
| Post-Translational Modification: | Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK. |
| Cellular Location: | Cytoplasm. Cell membrane. Membrane. Colocalizes with DAB2IP at the plasma membrane. |
| Database Links: |
|
| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
相关文章
