产品详情
简单介绍：
Anti-Cox-2 (T594) Antibody
详情介绍：
Overview
| Name: | Anti-Cox-2 (T594) Antibody See all Cox2 primary antibodies
|
| Description: | Rabbit polyclonal antibody to Cox-2 (T594) |
| Specificity: | Cox2 (T594) pAb detects endogenous levels of Cox2 protein. |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide, corresponding to amino acids C-terminus of Human Cox-2. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Molecular Weight: | ~ 74 kDa |
| Purity: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Product Form: | 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Target
| Function: | Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. |
| Sequence Similarities: | Belongs to the prostaglandin G/H synthase family. |
| Post-Translational Modification: | S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-526. |
| Cellular Location: | Microsome membrane. Endoplasmic reticulum membrane. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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