产品详情
简单介绍：
Anti-Cytokeratin 18 Antibody
详情介绍：
Overview
| Name: | Anti-Cytokeratin 18 Antibody See all Cytokeratin 18 primary antibodies
|
| Description: | Mouse monoclonal (DA-7) antibody to Cytokeratin 18 (Biotin). |
| Specificity: | The antibody DA-7 reacts with Cytokeratin 18 (45 kDa). Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues. |
| Applications: | IP, WB, IHC-P, ICC, ELISA |
| Reactivity: | Human |
| Immunogen: | Human breast carcinoma cell line PMC-42. |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Clone: | DA-7 |
| Isotype: | IgG1 |
| Conjugate: | Biotin |
| Concentration: | 1 mg/ml |
| Product Form: | Liquid |
| Formulation: | Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide. |
| Storage: | Store at 2-8°C. |
Target
| Function: | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. |
| Tissue Specificity: | Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. |
| Involvement in Disease: | Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension. |
| Sequence Similarities: | Belongs to the intermediate filament family. |
| Post-Translational Modification: | Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. |
| Cellular Location: | Cytoplasm > Perinuclear region. Nucleus > Nucleolus. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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