产品详情
简单介绍：
Anti-DGAT1 Antibody
详情介绍：
Overview
| Name: | Anti-DGAT1 Antibody See all DGAT1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to DGAT1 |
| Specificity: | The antibody detects endogenous levels of total DGAT1 protein. |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide corresponding to a region derived from internal residues of human diacylglycerol O-acyltransferase 1 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification. |
| Concentration: | 2.8mg / ml |
| Formulation: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. |
| Involvement in Disease: | Diarrhea 7: A life-threatening disease characterized by severe, intractable, watery diarrhea. |
| Sequence Similarities: | Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily. |
| Cellular Location: | Endoplasmic reticulum membrane. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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