产品详情
简单介绍：
Anti-DIABLO Antibody
详情介绍：
Overview
| Name: | Anti-DIABLO Antibody See all DIABLO primary antibodies
|
| Description: | Rabbit polyclonal antibody to DIABLO |
| Specificity: | The antibody detects endogenous level of total DIABLO protein. |
| Applications: | E, WB, IHC |
| Reactivity: | Human |
| Immunogen: | Fusion protein corresponding to a region derived from 56-239 amino acids of human diablo, IAP-binding mitochondrial protein |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Formulation: | Supplied at 2.2mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol. |
| Storage: | Store at -20?C / 1 year |
Target
| Function: | Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. |
| Tissue Specificity: | Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. |
| Involvement in Disease: | Deafness, autosomal dominant, 64: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. |
| Post-Translational Modification: | Ubiquitinated by BIRC7/livin. |
| Cellular Location: | Mitochondrion. Released into the cytosol when cells undergo apoptosis. |
| Database Links: |
|
| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
相关文章
