产品详情
简单介绍：
Anti-eIF3K Antibody
详情介绍：
Overview
| Name: | Anti-eIF3K Antibody See all eIF3K primary antibodies
|
| Description: | Rabbit polyclonal antibody to eIF3K |
| Applications: | WB, IF |
| Reactivity: | Human |
| Immunogen: | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 133 (Q9UBQ5) of EIF3K |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Affinity purified by Protein A. |
| Formulation: | Supplied in 1XPBS, 1%BSA, 20% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative. |
| Storage: | Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use. |
Target
| Function: | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). |
| Tissue Specificity: | Ubiquitous, with the highest levels of expression in brain, testis and kidney. |
| Sequence Similarities: | Belongs to the eIF-3 subunit K family. |
| Cellular Location: | Nucleus. Cytoplasm. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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