产品详情
简单介绍：
Anti-Ephrin-A1 Antibody
详情介绍：
Overview
| Name: | Anti-Ephrin-A1 Antibody See all Ephrin-A1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to Ephrin-A1 |
| Specificity: | Ephrin-A1 Polyclonal Antibody detects endogenous levels of Ephrin-A1 protein. |
| Applications: | WB, IHC, IF, ELISA |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the Internal region of human Ephrin-A1. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1mg / ml |
| Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage: | Store at -20?C / 1 year |
Target
| Function: | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. |
| Tissue Specificity: | Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). |
| Sequence Similarities: | Belongs to the ephrin family. |
| Post-Translational Modification: | Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form. |
| Cellular Location: | Cell membrane. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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