产品详情
简单介绍：
Anti-Epsin 1 Antibody
详情介绍：
Overview
| Name: | Anti-Epsin 1 Antibody See all Epsin 1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to Epsin 1 |
| Specificity: | Epsin 1 Polyclonal Antibody detects endogenous levels of Epsin 1 protein. |
| Applications: | WB, ELISA |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the Internal region of human Epsin 1. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1mg / ml |
| Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage: | Store at -20˚C / 1 year |
Target
| Function: | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis. |
| Sequence Similarities: | Belongs to the epsin family. |
| Post-Translational Modification: | Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation. |
| Cellular Location: | Cytoplasm. Cell membrane. Nucleus. Membrane > Clathrin-coated pit. Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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