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产品详情
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  • 产品名称:Recombinant Human Tumor necrosis factor protein(TNF) (Active)

  • 产品型号:
  • 产品厂商:其它品牌
  • 产品价格:0
  • 折扣价格:0
  • 产品文档:
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简单介绍:
Recombinant Human Tumor necrosis factor protein(TNF) (Active)
详情介绍:
  • 产品类型:
    Tumor Necrosis Factor
  • 产品名称:

    Recombinant Human Tumor necrosis factor protein(TNF) (Active)

  • uniprot号:
  • 规格:
    ¥620
  • 图像:

  • 基因名称:
    TNF
  • 别名:
    Cachectin, Tumor necrosis factor ligand superfamily member 2, TNF-a, , NTF
  • 种属:
    Homo sapiens (Human)
  • 蛋白描述:
    Partial
  • PubMed ID:
    3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 14656967; 15489334; 8631363; 8597870; 10205166; 2009860; 1402651; 9034191; 10369255; 16829952; 16829951; 22517918; 23396208; 2922050; 1964681; 2551905; 9488135; 9442056; 12746914; 12915457
  • 分子量:
    16.9 kDa
  • 标签信息:
    Tag-Free
  • 来源:
    E.Coli
  • 纯度:
    >98% as determined by SDS-PAGE and HPLC.
  • 缓冲液:
    0.2 m filtered 20 mM PB, 10 mM Nacl, pH 7.0 ,lyophilized
  • 内毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    Fully biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 0.01 ng/ml, corresponding to a specific activity of >1.0x108 IU/mg in the presence of actinomycin D.
  • Uniprot登录名:
    TNFA_HUMAN
  • 参考文献:
    Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918). {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:22517918, ECO:0000269|PubMed:23396208}.; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. {ECO:0000269|PubMed:16829952}.
  • 氨基酸序列:
    MRKR+KPVAHV VANPQAEGQL QWLNRRANAL LANGVELRDN QLVVPSEGLY LIYSQVLFKG QGCPSTHVLL THTISRIAVS YQTKVNLLSA IKSPCQRETP EGAEAKPWYE PIYLGGVFQL EKGDRLSAEI NRPDYLDFAE SGQVYFGIIA F
  • 表达区域:
    87-233aa
  • 研究领域:
    Cancer
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