产品类型:

Interleukin

产品名称:

Recombinant Human Interleukin-1 receptor antagonist protein(IL1RN) (Active)

uniprot号:

规格:

20μg 100μg 250μg ￥620

图像:

基因名称:

IL1RN

别名:

IL-1RN, IRAP, ICIL-1RA, IL1 inhibitor, Anakinra

种属:

Homo sapiens (Human)

蛋白描述:

Full Length of Mature Protein

PubMed ID:

2139180; 2137201; 1828896; 1385987; 8992991; 1827201; 7629520; 14702039; 15815621; 15489334; 2137200; 2143761; 9514884; 7989776; 7775431; 11991722; 8786086; 16335952; 19494218; 1534997; 8045306; 8175703; 7867645; 9062194; 18987736

分子量:

17.1 kDa

标签信息:

Tag-Free

来源:

E.Coli

纯度:

>96% as determined by SDS-PAGE and HPLC.

缓冲液:

0.2 μm filtered PBS, pH 7.4 ,lyophilized

内毒素:

Less than 1.0 EU/μg as determined by LAL method.

生物活性:

Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1α- dependent proliferation of murine D10S cells is less than 40 ng/ml, corresponding to a specific activity of >2.5x10⁴ IU/mg in the presence of 50 pg/ml rHuIL-1α.

Uniprot登录名:

IL1RA_HUMAN

参考文献:

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. {ECO:0000269|PubMed:7775431}.

氨基酸序列:

RPSGRKSSKM QAFRIWDVNQ KTFYLRNNQL VAGYLQGPNV NLEEKIDVVP IEPHALFLGI HGGKMCLSCV KSGDETRLQL EAVNITDLSE NRKQDKRFAF IRSDSGPTTS FESAACPGWF LCTAMEADQP VSLTNMPDEG VMVTKFYFQE DE

表达区域:

26-177aa

研究领域:

Immunology