产品类型:

Other

产品名称:

Recombinant Mouse Sonic hedgehog protein(Shh) (Active)

uniprot号:

规格:

5μg 25μg 100μg 250μg ￥620

图像:

基因名称:

Shh

别名:

SHH, ,; Sonic hedgehog protein C-product Sonic hedgehog protein 27 kDa product,]

种属:

Mus musculus (Mouse)

蛋白描述:

Partial

PubMed ID:

7916661; 7720571; 16141072; 15489334; 7891723; 7736596; 8824192; 11486055; 14687547; 15075292; 16282375; 18081866; 7477329; 18794898; 19561611; 20519495

分子量:

19.8 kDa

标签信息:

Tag-Free

来源:

E.Coli

纯度:

>95% as determined by SDS-PAGE and HPLC.

缓冲液:

0.2 μm filtered 20 mM PB, pH 7.4, 150mM NaCl ,lyophilized

内毒素:

Less than 1.0 EU/μg as determined by LAL method.

生物活性:

Fully biologically active when compared to standard. The ED50 as determined by inducing alkaline phosphatase production of murine C3H10T1/2 cells is 0.5 - 1.0 μg/ml.

Uniprot登录名:

SHH_MOUSE

参考文献:

Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO. {ECO:0000269|PubMed:14687547, ECO:0000269|PubMed:7736596}.

氨基酸序列:

IVIGPGRGFG KRRHPKKLTP LAYKQFIPNV AEKTLGASGR YEGKITRNSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDKLNALAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRAVDITTS DRDRSKYGML ARLAVEAGFD WVYYESKAHI HCSVKAENSV AAKSGG

表达区域:

26-198aa

研究领域:

Cancer