产品详情
简单介绍:
Recombinant Human Midkine protein(MDK) (Active)
详情介绍:
Other
Recombinant Human Midkine protein(MDK) (Active)
¥620
MDK
MK, ARAP, Midgestation and kidney protein, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein
Homo sapiens (Human)
Full Length of Mature Protein
2025291; 1768439; 1639750; 8471163; 17379400; 16554811; 15489334; 1883381; 8241100; 15340161; 12122009; 9384573
13.4 kDa
Tag-Free
E.Coli
>97% as determined by SDS-PAGE and HPLC.
0.2 μm filtered PBS, pH7.4 ,lyophilized
Less than 1.0 EU/μg as determined by LAL method.
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 0.1-10 ng/ml.
MK_HUMAN
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). {ECO:0000250}.
VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD
21-143aa
Neuroscience?
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