Forskolin 毛喉素 现货 Geneoperation

Forskolin 毛喉素 现货 Geneoperation

Forskolin是一种天然化合物。由于其具有使神经细胞分化的功能，用于许多细胞分化过程，Forskolin能刺激腺苷酸环化酶的活性并增加cAMP，cAMP是一个信号分子，是细胞发生过程中关键酶的调节因子。Forskolin可以通透细胞，激活腺苷酸环化酶(adenylyl cyclase)，从而升高细胞内的cAMP水平。例如，cAMP能与蛋白激酶A(PKA)的调节亚基结合，激活PKA的活性，作为hedgehog信号路径的阴性调节因子。

产品信息：

CAS #: 66575-29-9

Synonyms: Colforsin; 7-beta-acetoxy-8,13-epoxy-1-alpha, 6-beta, 9-alpha-trihydroxylabd-14-en-11-one;Coleonol

Appearance: White to white with yellow cast powder

Melting Point: 230-232°C 1

Molecular formula: C22H34O7

Molecular weight: 410.5 (anhydrous)

Specific Rotation: -26.19° where c = 1.68% in

chloroform at 25EC 2

Absorbance max: 210 nm (E molar = 1000)

305 nm (E molar = 50)3

Purity: Not less than 98% (HPLC)

Forskolin is a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory and adenylate cyclase activating properties.The activation of adenylate cyclase results in increased intracellular cyclic AMP in most tissue and cells.Sigma’s product is prepared by grinding Coleus forskohlii roots followed by extraction and then purification by silica chromatography.

产品使用指南：

Forskolin is soluble in organic solvents such as ethanol,chloroform and DMSO. Sigma routinely tests its solubility in chloroform at 50 mg/mL and observes a clear, colorless to pale yellow solution. Forskolin is soluble in water (with 2% ethanol) up to 0.2 mM by first dissolving in ethanol at 5 mg/mL and doing subsequent dilutions with water. Similar results were found with DMSO.4 Please note, however, that various solvents, including ethanol, inhibited the forskolin activation of adenylate cyclase. DMSO is recommended for preparing forskolin solutions because at concentrations of 5% or less of DMSO, there is little if any inhibition of forskolin activation.Forskolin solutions at 5 mg/mL in either ethanol or DMSO were stable for at least 6 months at room temperature per HPLC analysis.

产品保存：

粉末保存在2~8°，3年内有效；溶液保存在-20°，2年内有效。

订购信息：产品来源Sigma公司

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