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- 产品名称：H-89, Dihydrochloride Salt, >99%
- 产品型号：H-5239
- 产品展商：Geneoperation
- 产品文档：无相关文档
- 发布时间：2018-08-28
- 在线询价
简单介绍
M.W. 519.28
C20H20BrN3O2S•2HCl
[127243-85-0]
产品描述
Storage: Store desiccated at or below -20 ºC. Solubility: Soluble in DMSO, water (up to 25 mg/mL; heat to dissolve), or ethanol/water. Disposal: A
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Potent and selective inhibitor of PKA, with an IC50 of about 50 nM. Chijiwa, T., et al. "Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells." J. Biol. Chem. 265: 5267-5272 (1990).
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Also inhibits PKG and the µ isotype of PKC (at about 500 nM). In contrast, most other PKC isotypes are much more weakly inhibited, with IC50's in the 32 µM range. Johannes, F.-J., Prestle, J., Dieterich, S., Oberhagemann, P., Link, G. and Pfizenmaier, K. "Characterization of activators and inhibitors of protein kinase Cµ." Eur. J. Biochem. 227: 303-307 (1995).
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Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
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