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- 产品名称：Tyrphostin AG 1478, Free Base, >99%
- 产品型号：T-7310
- 产品展商：Geneoperation
- 产品文档：无相关文档
- 发布时间：2018-07-18
- 在线询价
简单介绍
M.W. 315.75
C16H14ClN3O2
[175178-82-2]
产品描述
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO, to about 60 mg/ml; poorly soluble in ethanol. Appearance: White solid. Disposal: A
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View the MSDS for this product
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Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50 = 3 nM). Very weak on PDGF receptor and HER2-NEU kinases (IC50 >100 µM). Osherov, N. and Levitzki, A. "Epidermal-growth-factor-dependent activation of the src-family kinases." Eur. J. Biochem. 225: 1047-1053 (1994). Levitzki, A. and Gazit, A. "Tyrosine kinase inhibition: an approach to drug development." Science 267: 1782-1788 (1995).
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Reversibly inhibits (IC50 = 9.8 µM) the rat brain Kv1.5 potassium channel in vitro in a non-protein-tyrosine-kinase-mediated manner. Choi, B.H., et al. "Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitor." Am. J. Physiol. Cell Physiol. 282: C1461-C1468 (2002).
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Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
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